Publications: Titus Boggon
| Title | Year | Citations | Score |
|---|---|---|---|
|
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
Science 304 (5676), 1497-1500, 2004 View Details |
2004 | 11814 | 100.0% |
|
EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib
New England Journal of Medicine 352 (8), 786-792, 2005 View Details |
2005 | 4713 | 99.8% |
|
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
Cancer cell 7 (4), 387-397, 2005 View Details |
2005 | 3779 | 99.7% |
|
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Nature genetics 44 (9), 1006-1014, 2012 View Details |
2012 | 1305 | 98.7% |
|
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer
Nature genetics 44 (8), 852-860, 2012 View Details |
2012 | 1256 | 98.7% |
|
Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity
Cancer cell 11 (3), 217-227, 2007 View Details |
2007 | 1183 | 98.1% |
|
Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
Science signaling 2 (97), ra73-ra73, 2009 View Details |
2009 | 822 | 97.4% |
|
Structure and regulation of Src family kinases
Oncogene 23 (48), 7918-7927, 2004 View Details |
2004 | 900 | 96.8% |
|
Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation
Nature genetics 46 (10), 1135-1139, 2014 View Details |
2014 | 490 | 96.3% |
|
C-cadherin ectodomain structure and implications for cell adhesion mechanisms
Science 296 (5571), 1308-1313, 2002 View Details |
2002 | 837 | 96.1% |
|
Genomic landscape of cutaneous T cell lymphoma
Nature genetics 47 (9), 1011-1019, 2015 View Details |
2015 | 418 | 95.7% |
|
BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
PLoS medicine 4 (10), e315, 2007 View Details |
2007 | 577 | 95.3% |
|
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
Cancer cell 22 (5), 585-600, 2012 View Details |
2012 | 409 | 94.4% |
|
Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
Cancer cell 27 (2), 257-270, 2015 View Details |
2015 | 316 | 93.8% |
|
The structure and clinical relevance of the EGF receptor in human cancer
Journal of clinical oncology: official journal of the American Society of …, 2008 View Details |
2008 | 447 | 93.7% |
|
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma
Proceedings of the National Academy of Sciences 110 (8), 2916-2921, 2013 View Details |
2013 | 304 | 92.5% |
|
Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex
Molecular cell 53 (4), 534-548, 2014 View Details |
2014 | 272 | 92.2% |
|
Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
Molecular cell 44 (6), 864-877, 2011 View Details |
2011 | 332 | 92.2% |
|
G-protein signaling through tubby proteins
Science 292 (5524), 2041-2050, 2001 View Details |
2001 | 448 | 91.8% |
|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1–AMPK signalling
Nature cell biology 17 (11), 1484-1496, 2015 View Details |
2015 | 242 | 91.6% |
|
Activating alleles of JAK3 in acute megakaryoblastic leukemia
Cancer cell 10 (1), 65-75, 2006 View Details |
2006 | 357 | 91.3% |
|
Activating alleles of JAK3 in acute megakaryoblastic leukemia
Cancer cell 10 (1), 65-75, 2006 View Details |
2006 | 357 | 91.3% |
|
Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial–mesenchymal transition
Proceedings of the National Academy of Sciences 113 (43), 12238-12243, 2016 View Details |
2016 | 195 | 90.3% |
|
Tyrosine Phosphorylation of Lactate Dehydrogenase A Is Important for NADH/NAD+ Redox Homeostasis in Cancer Cells
Molecular and cellular biology 31 (24), 4938-4950, 2011 View Details |
2011 | 246 | 89.1% |
|
Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration
Proceedings of the National Academy of Sciences 110 (9), 3489-3494, 2013 View Details |
2013 | 199 | 87.8% |
|
EGFR-mutated lung cancer: a paradigm of molecular oncology
Oncotarget 1 (7), 497, 2010 View Details |
2010 | 232 | 87.3% |
|
RAC1P29S is a spontaneously activating cancer-associated GTPase
Proceedings of the National Academy of Sciences 110 (3), 912-917, 2013 View Details |
2013 | 188 | 87.0% |
|
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p. Q575E)
Blood, The Journal of the American Society of Hematology 130 (12), 1430-1440, 2017 View Details |
2017 | 135 | 86.4% |
|
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles
Cancer cell 12 (6), 501-513, 2007 View Details |
2007 | 225 | 86.0% |
|
Implication of tubby proteins as transcription factors by structure-based functional analysis
Science 286 (5447), 2119-2125, 1999 View Details |
1999 | 251 | 85.7% |
|
Mineralocorticoid receptor phosphorylation regulates ligand binding and renal response to volume depletion and hyperkalemia
Cell metabolism 18 (5), 660-671, 2013 View Details |
2013 | 171 | 85.7% |
|
Integrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity
Blood, The Journal of the American Society of Hematology 138 (14), 1225-1236, 2021 View Details |
2021 | 56 | 85.2% |
|
Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development
Science signaling 3 (116), ra26-ra26, 2010 View Details |
2010 | 194 | 84.6% |
|
Metabolic rewiring by oncogenic BRAF V600E links ketogenesis pathway to BRAF-MEK1 signaling
Molecular cell 59 (3), 345-358, 2015 View Details |
2015 | 137 | 84.1% |
|
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
Blood 106 (3), 996-1002, 2005 View Details |
2005 | 200 | 83.1% |
|
MAST1 drives cisplatin resistance in human cancers by rewiring cRaf-independent MEK activation
Cancer cell 34 (2), 315-330. e7, 2018 View Details |
2018 | 99 | 83.1% |
|
Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth
Molecular cell 55 (4), 552-565, 2014 View Details |
2014 | 133 | 82.7% |
|
Data publication with the structural biology data grid supports live analysis
Nature communications 7 (1), 10882, 2016 View Details |
2016 | 104 | 80.9% |
|
Cerebral cavernous malformation proteins at a glance
Journal of cell science 127 (4), 701-707, 2014 View Details |
2014 | 114 | 79.8% |
|
Structural and numerical variation of FLT3/ITD in pediatric AML
Blood, The Journal of the American Society of Hematology 111 (10), 4930-4933, 2008 View Details |
2008 | 143 | 78.9% |
|
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy
Proceedings of the National Academy of Sciences 116 (45), 22730-22736, 2019 View Details |
2019 | 63 | 78.3% |
|
Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity
Molecular cell 53 (1), 140-147, 2014 View Details |
2014 | 102 | 77.5% |
|
Screening for phasing atoms in protein crystallography
Structure 8 (7), R143-R149, 2000 View Details |
2000 | 153 | 76.9% |
|
Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation
Molecular cell 49 (4), 719-729, 2013 View Details |
2013 | 105 | 76.9% |
|
JAK2 T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
Blood 108 (8), 2770-2779, 2006 View Details |
2006 | 135 | 76.8% |
|
Tetrameric acetyl-CoA acetyltransferase 1 is important for tumor growth
Molecular cell 64 (5), 859-874, 2016 View Details |
2016 | 83 | 76.1% |
|
Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex
Nature communications 6 (1), 7937, 2015 View Details |
2015 | 87 | 75.3% |
|
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
Proceedings of the National Academy of Sciences 109 (40), 16107-16112, 2012 View Details |
2012 | 104 | 75.3% |
|
Trends and challenges in experimental macromolecular crystallography
Quarterly reviews of biophysics 29 (3), 227-278, 1996 View Details |
1996 | 119 | 75.1% |
|
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
Nature communications 4 (1), 1790, 2013 View Details |
2013 | 93 | 74.2% |
|
Tyr-301 phosphorylation inhibits pyruvate dehydrogenase by blocking substrate binding and promotes the Warburg effect
Journal of Biological Chemistry 289 (38), 26533-26541, 2014 View Details |
2014 | 83 | 72.8% |
|
The structural basis of integrin-linked kinase–PINCH interactions
Proceedings of the National Academy of Sciences 105 (52), 20677-20682, 2008 View Details |
2008 | 104 | 72.2% |
|
Cisplatin-mediated activation of glucocorticoid receptor induces platinum resistance via MAST1
Nature communications 12 (1), 4960, 2021 View Details |
2021 | 29 | 71.6% |
|
Genetic abnormalities of the EGFR pathway in African American patients with non–small-cell lung cancer
Journal of Clinical Oncology 27 (33), 5620, 2009 View Details |
2009 | 97 | 71.3% |
|
Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension
Hepatology 63 (6), 1977-1986, 2016 View Details |
2016 | 67 | 71.1% |
|
Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation
Journal of cell science 127 (19), 4308-4321, 2014 View Details |
2014 | 77 | 71.0% |
|
Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity
Journal of Biological Chemistry 285 (31), 24099-24107, 2010 View Details |
2010 | 94 | 70.8% |
|
Constrained chromatin accessibility in PU. 1-mutated agammaglobulinemia patients
Journal of Experimental Medicine 218 (7), e20201750, 2021 View Details |
2021 | 28 | 70.6% |
|
A network of interactions enables CCM3 and STK24 to coordinate UNC13D-driven vesicle exocytosis in neutrophils
Developmental cell 27 (2), 215-226, 2013 View Details |
2013 | 79 | 70.4% |
|
Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML
Blood 104 (6), 1855-1858, 2004 View Details |
2004 | 104 | 70.1% |
|
Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology
Cellular and molecular life sciences 71, 1881-1892, 2014 View Details |
2014 | 73 | 69.6% |
|
JAK3: a two-faced player in hematological disorders
The international journal of biochemistry & cell biology 41 (12), 2376-2379, 2009 View Details |
2009 | 89 | 69.4% |
|
Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity
Proceedings of the National Academy of Sciences 107 (20), 9176-9181, 2010 View Details |
2010 | 85 | 68.6% |
|
Bound-solvent structures for microgravity-, ground control-, gel-and microbatch-grown hen egg-white lysozyme crystals at 1.8 Å resolution
Acta Crystallographica Section D: Biological Crystallography 55 (4), 745-752, 1999 View Details |
1999 | 92 | 68.5% |
|
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin
Oncogene 36 (2), 254-262, 2017 View Details |
2017 | 55 | 68.1% |
|
De novo mutations in the BMP signaling pathway in lambdoid craniosynostosis
Human Genetics 142 (1), 21-32, 2023 View Details |
2023 | 9 | 67.9% |
|
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output
PLoS biology 17 (3), e2006540, 2019 View Details |
2019 | 41 | 67.9% |
|
γ-6-Phosphogluconolactone, a byproduct of the oxidative pentose phosphate pathway, contributes to AMPK activation through inhibition of PP2A
Molecular cell 76 (6), 857-871. e9, 2019 View Details |
2019 | 41 | 67.9% |
|
The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization
Journal of Biological Chemistry 293 (5), 1642-1650, 2018 View Details |
2018 | 48 | 67.6% |
|
Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis
Journal of Biological Chemistry 283 (42), 28305-28312, 2008 View Details |
2008 | 83 | 67.3% |
|
Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
Molecular and cellular biology 29 (8), 2105-2117, 2009 View Details |
2009 | 80 | 66.9% |
|
Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells
Proceedings of the National Academy of Sciences 107 (7), 2866-2871, 2010 View Details |
2010 | 79 | 66.9% |
|
Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies
Cancer research 67 (21), 10417-10427, 2007 View Details |
2007 | 82 | 66.7% |
|
Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth
Journal of Biological Chemistry 289 (31), 21413-21422, 2014 View Details |
2014 | 64 | 66.3% |
|
Signaling, regulation, and specificity of the type II p21-activated kinases
Journal of Biological Chemistry 290 (21), 12975-12983, 2015 View Details |
2015 | 59 | 65.9% |
|
Synchrotron X-ray reciprocal-space mapping, topography and diffraction resolution studies of macromolecular crystal quality
Acta Crystallographica Section D: Biological Crystallography 56 (7), 868-880, 2000 View Details |
2000 | 83 | 64.8% |
|
Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy
Translational Research 208, 15-29, 2019 View Details |
2019 | 36 | 64.4% |
|
Structural basis for noncanonical substrate recognition of cofilin/ADF proteins by LIM kinases
Molecular cell 62 (3), 397-408, 2016 View Details |
2016 | 51 | 64.3% |
|
MERTK controls melanoma cell migration and survival and differentially regulates cell behavior relative to AXL
Pigment cell & melanoma research 26 (4), 527-541, 2013 View Details |
2013 | 61 | 64.2% |
|
Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1)
Journal of Biological Chemistry 287 (26), 22317-22327, 2012 View Details |
2012 | 63 | 63.4% |
|
CCM2–CCM3 interaction stabilizes their protein expression and permits endothelial network formation
Journal of Cell Biology 208 (7), 987-1001, 2015 View Details |
2015 | 52 | 62.5% |
|
Calcium-induced conformational changes in C-terminal tail of polycystin-2 are necessary for channel gating
Journal of Biological Chemistry 287 (21), 17232-17240, 2012 View Details |
2012 | 61 | 62.5% |
|
Identification of PLX 4032‐resistance mechanisms and implications for novel RAF inhibitors
Pigment cell & melanoma research 27 (2), 253-262, 2014 View Details |
2014 | 55 | 62.4% |
|
The use of structural biology in Janus kinase targeted drug discovery
Current drug targets 12 (4), 546-555, 2011 View Details |
2011 | 60 | 61.2% |
|
Global analysis of human non-receptor tyrosine kinase specificity using high-density peptide microarrays
Journal of proteome research, 2014 View Details |
2014 | 47 | 58.3% |
|
Partial improvement of crystal quality for microgravity-grown apocrustacyanin C1
Acta Crystallographica Section D: Biological Crystallography 53 (3), 231-239, 1997 View Details |
1997 | 53 | 57.8% |
|
Mutations in TFAP2B and previously unimplicated genes of the BMP, Wnt, and Hedgehog pathways in syndromic craniosynostosis
Proceedings of the National Academy of Sciences 116 (30), 15116-15121, 2019 View Details |
2019 | 27 | 56.4% |
|
Mutant and wild-type isocitrate dehydrogenase 1 share enhancing mechanisms involving distinct tyrosine kinase cascades in cancer
Cancer discovery 9 (6), 756-777, 2019 View Details |
2019 | 26 | 55.4% |
|
CDC42 binds PAK4 via an extended GTPase-effector interface
Proceedings of the National Academy of Sciences 115 (3), 531-536, 2018 View Details |
2018 | 30 | 55.1% |
|
Protein crystal movements and fluid flows during microgravity growth
Philosophical Transactions of the Royal Society of London. Series A …, 1998 View Details |
1998 | 46 | 55.1% |
|
Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations
Journal of Biological Chemistry 290 (5), 2842-2853, 2015 View Details |
2015 | 39 | 54.9% |
|
SH2 domain binding: diverse FLVRs of partnership
Frontiers in Endocrinology 11, 575220, 2020 View Details |
2020 | 21 | 54.6% |
|
Analysis of the cytoplasmic interaction between polycystin-1 and polycystin-2
American Journal of Physiology-Renal Physiology 297 (5), F1310-F1315, 2009 View Details |
2009 | 44 | 53.2% |
|
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells
Molecular Cell 81 (18), 3833-3847. e11, 2021 View Details |
2021 | 15 | 53.2% |
|
Lysozyme crystal growth kinetics monitored using a Mach–Zehnder interferometer
Acta Crystallographica Section D: Biological Crystallography 52 (3), 529-533, 1996 View Details |
1996 | 38 | 52.7% |
|
Structural basis for paxillin binding and focal adhesion targeting of β-parvin
Journal of Biological Chemistry 287 (39), 32566-32577, 2012 View Details |
2012 | 40 | 52.2% |
|
Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry
Nature communications 13 (1), 749, 2022 View Details |
2022 | 9 | 51.7% |
|
SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP
Nature Communications 13 (1), 4788, 2022 View Details |
2022 | 9 | 51.7% |
|
Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3)
Journal of Biological Chemistry 286 (29), 26138-26147, 2011 View Details |
2011 | 39 | 51.0% |
|
Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus
FEBS letters 587 (3), 272-277, 2013 View Details |
2013 | 36 | 50.7% |
|
The Crystal Structure Analysis of d(CGCGAASSCGCG)2, a Synthetic DNA Dodecamer Duplex Containing Four 4′-Thio-2′-Deoxythymidine Nucleotides
Nucleic acids research 24 (5), 951-961, 1996 View Details |
1996 | 34 | 50.5% |
|
CCD video observation of microgravity crystallization of lysozyme and correlation with accelerometer data
Acta Crystallographica Section D: Biological Crystallography 53 (6), 747-755, 1997 View Details |
1997 | 35 | 49.8% |
|
PAK6 targets to cell–cell adhesions through its N-terminus in a Cdc42-dependent manner to drive epithelial colony escape
Journal of cell science 129 (2), 380-393, 2016 View Details |
2016 | 29 | 49.0% |
|
Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region
Proceedings of the National Academy of Sciences 110 (44), 17832-17837, 2013 View Details |
2013 | 32 | 47.9% |
|
Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1)
Journal of Biological Chemistry 289 (36), 25362-25373, 2014 View Details |
2014 | 31 | 47.9% |
|
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer
Molecular cell 57 (1), 191-201, 2015 View Details |
2015 | 28 | 46.5% |
|
p90 RSK2 mediates antianoikis signals by both transcription-dependent and-independent mechanisms
Molecular and cellular biology 33 (13), 2574-2585, 2013 View Details |
2013 | 30 | 46.3% |
|
p190RhoGAP proteins contain pseudoGTPase domains
Nature communications 8 (1), 506, 2017 View Details |
2017 | 23 | 45.3% |
|
Structural basis of competition between PINCH1 and PINCH2 for binding to the ankyrin repeat domain of integrin-linked kinase
Journal of structural biology 170 (1), 157-163, 2010 View Details |
2010 | 28 | 43.8% |
|
De novo variants implicate chromatin modification, transcriptional regulation, and retinoic acid signaling in syndromic craniosynostosis
The American Journal of Human Genetics 110 (5), 846-862, 2023 View Details |
2023 | 4 | 43.7% |
|
Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6
PLoS One 8 (10), e77818, 2013 View Details |
2013 | 25 | 42.2% |
|
Disruption of the EGFR E884–R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity
Oncogene 28 (4), 518-533, 2009 View Details |
2009 | 25 | 41.9% |
|
Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition
Journal of structural biology 181 (3), 243-251, 2013 View Details |
2013 | 22 | 39.6% |
|
Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide
PLoS One 14 (12), e0226113, 2019 View Details |
2019 | 14 | 39.0% |
|
The pseudoGTPase group of pseudoenzymes
The FEBS journal 287 (19), 4232-4245, 2020 View Details |
2020 | 12 | 39.0% |
|
Apocrustacyanin C1 crystals grown in space and on earth using vapour-diffusion geometry: protein structure refinements and electron-density map comparisons
Acta Crystallographica Section D: Biological Crystallography 59 (7), 1117-1123, 2003 View Details |
2003 | 20 | 38.8% |
|
Purification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric complex
PloS one 8 (1), e55591, 2013 View Details |
2013 | 20 | 37.6% |
|
Discovery and functional validation of novel pediatric specific FLT3 activating mutations in acute myeloid leukemia: results from the COG/NCI target initiative
Blood 126 (23), 87, 2015 View Details |
2015 | 19 | 37.5% |
|
Purification, crystallization and initial X-ray analysis of the C1 subunit of the astaxanthin protein, V600, of the chondrophore Velella velella
Acta Crystallographica Section D: Biological Crystallography 55 (1), 266-268, 1999 View Details |
1999 | 15 | 34.7% |
|
The GTPase-activating protein p120RasGAP has an evolutionarily conserved “FLVR-unique” SH2 domain
Journal of Biological Chemistry 295 (31), 10511-10521, 2020 View Details |
2020 | 10 | 34.4% |
|
Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1
Journal of Biological Chemistry 299 (9), 2023 View Details |
2023 | 3 | 34.3% |
|
AIP1 expression in tumor niche suppresses tumor progression and metastasis
Cancer research 75 (17), 3492-3504, 2015 View Details |
2015 | 16 | 34.0% |
|
Structure of the ABL2/ARG kinase in complex with dasatinib
Acta Crystallographica Section F: Structural Biology Communications 71 (4 …, 2015 View Details |
2015 | 16 | 34.0% |
|
PAK4 crystal structures suggest unusual kinase conformational movements
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1866 (2), 356-365, 2018 View Details |
2018 | 13 | 33.9% |
|
Two amino acid residues confer different binding affinities of Abelson family kinase SRC homology 2 domains for phosphorylated cortactin
Journal of Biological Chemistry 289 (28), 19704-19713, 2014 View Details |
2014 | 15 | 32.5% |
|
Recognition of physiological phosphorylation sites by p21-activated kinase 4
Journal of structural biology 211 (3), 107553, 2020 View Details |
2020 | 9 | 31.9% |
|
Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin–Arg–lysozyme complex
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2012 View Details |
2012 | 15 | 31.8% |
|
Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD–FERM interface
Journal of structural biology 192 (3), 449-456, 2015 View Details |
2015 | 14 | 31.5% |
|
Automated protein crystallization trials using the Thermo Scientific Matrix Hydra II eDrop
JALA: Journal of the Association for Laboratory Automation 12 (4), 213-218, 2007 View Details |
2007 | 13 | 30.6% |
|
The N-terminal GTPase domain of p190RhoGAP proteins is a pseudoGTPase
Structure 26 (11), 1451-1461. e4, 2018 View Details |
2018 | 11 | 30.5% |
|
PseudoGTPase domains in p190RhoGAP proteins: a mini-review
Biochemical Society Transactions 46 (6), 1713-1720, 2018 View Details |
2018 | 10 | 28.8% |
|
Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide
Acta Crystallographica Section F: Structural Biology and Crystallization …, 2013 View Details |
2013 | 12 | 28.5% |
|
Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation
Molecular cell 82 (11), 1992-2005. e9, 2022 View Details |
2022 | 4 | 27.9% |
|
The cerebral cavernous malformations proteins
Oncotarget 6 (32), 32279, 2015 View Details |
2015 | 11 | 27.4% |
|
The repeat region of cortactin is intrinsically disordered in solution
Scientific reports 7 (1), 16696, 2017 View Details |
2017 | 9 | 25.7% |
|
Jak3 Kinase Domain Crystal Structures and Implications for Jak-Specific Drug Design.
Blood 106 (11), 69, 2005 View Details |
2005 | 7 | 23.0% |
|
SHP family protein tyrosine phosphatases adopt canonical active-site conformations in the apo and phosphate-bound states
Protein and peptide letters 20 (9), 1039-1048, 2013 View Details |
2013 | 8 | 22.6% |
|
Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP
Structure 30 (12), 1603-1614. e5, 2022 View Details |
2022 | 3 | 20.7% |
|
Rho family GTPase signaling through type II p21-activated kinases
Cellular and Molecular Life Sciences 79 (12), 598, 2022 View Details |
2022 | 3 | 20.7% |
|
Cerebral cavernous malformation gene CCM3 is critical for vascular development by regulating VEGFR2 signaling
Science signaling 3 (116), ra26, 2010 View Details |
2010 | 5 | 17.0% |
|
Correction: Crystal structures of p120RasGAP N-terminal SH2 domain in its apo form and in complex with a p190RhoGAP phosphotyrosine peptide
Plos one 15 (2), e0229627, 2020 View Details |
2020 | 4 | 16.5% |
|
Bim mediates EGFR tyrosine kinase inhibitor induced apoptosis in non-small cell lung cancers and is linked to the resistance conferred by secondary EGFR mutations, T790M and the novel L747S
Cancer Research 67 (9_Supplement), LB-61-LB-61, 2007 View Details |
2007 | 4 | 14.7% |
|
FGFR3 associates with and tyrosine-phosphorylates p90RSK2, leading to RSK2 activation that mediates hematopoietic transformation
Mol Cell Biol, 2009 View Details |
2009 | 3 | 11.7% |
|
Structure of the C-cadherin ectodomains and implications for the mecanism of cell adhesion
J. Phys. Chem 52, 125, 2002 View Details |
2002 | 2 | 6.9% |
|
P2-138: Disruption of a conserved ion pair E884-R958 in EGFR differentially alters kinase inhibitor sensitivity and downstream signaling
Journal of Thoracic Oncology 2 (8), S545-S546, 2007 View Details |
2007 | 2 | 6.6% |
|
Implication of tubby proteins as transcription factors by structure-based functional analysis
Acta Crystallographica Section A Foundations of Crystallography 56 (s1 …, 2000 View Details |
2000 | 2 | 6.5% |
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Differential binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation
J Cell Sci, 2014 View Details |
2014 | 2 | 6.3% |
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Protein crystal perfection and the crystal growth process
Acta Crystallographica Section A 52, C517-C517, 1996 View Details |
1996 | 1 | 0.0% |
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A Pressure Cell for Obtaining Xenon Derivatives from Protein Crystals and First Tests with Astaxanthin Binding Proteins
Daresbury Scientific Reports (1997-98), 252-253, 1998 View Details |
1998 | 1 | 0.0% |
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Biophysical and structural chemistry studies of lysozyme and astaxanthin binding proteins
PQDT-Global, 1998 View Details |
1998 | 1 | 0.0% |
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Predictive model of resistance mechanisms against irreversible EGFR inhibitors reveals novel treatment strategies
Cancer Research 67 (9_Supplement), 2555-2555, 2007 View Details |
2007 | 1 | 0.0% |
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Καρκίνος του πνεύμονα: δομές των μεταβολών στον υποδοχέα EGFR και στα κατασταλτικά συμπλέγματα
Cancer Cell 11, 217-227, 2007 View Details |
2007 | 1 | 0.0% |
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Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment
Blood 120 (21), 860, 2012 View Details |
2012 | 1 | 0.0% |
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Understanding the Molecular and Functional Mechanisms that Underlie Pharamcogenomics-Based Therapy
J Pharmacogenom Pharmacoproteomics 3 (4), 2012 View Details |
2012 | 1 | 0.0% |
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Mechanism for KRIT1 release of ICAP1-mediated integrin activation suppression
Molecular cell 49 (4), 719, 2013 View Details |
2013 | 1 | 0.0% |
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Tyr-phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate pyruvate dehydrogenase complex and promote the Warburg effect
Cancer Research 74 (19_Supplement), 3362-3362, 2014 View Details |
2014 | 1 | 0.0% |
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Clamping Together Hemidesmosomes and Latching Them in Place
Structure 27 (6), 881-883, 2019 View Details |
2019 | 1 | 0.0% |
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Crystallographic studies of the cerebral cavernous malformations proteins
Cerebral Cavernous Malformations (CCM) Methods and Protocols, 291-302, 2020 View Details |
2020 | 1 | 0.0% |
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Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations
Nature communications 14 (1), 7452, 2023 View Details |
2023 | 1 | 0.0% |
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Genetic dysregulation of an endothelial Ras signaling network in vein of Galen malformations
bioRxiv, 2023.03. 18.532837, 2023 View Details |
2023 | 1 | 0.0% |